![]() Gerbaulet AL, Kunkler IH, Kerr GR, Haie C, Michel G, Prade M, Lhomme C, Masselot M, Albano M, Dutreix A and Chassagne D. GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide, Version 1.0. Genome Biol., 4, P3.įerlay F, Bray F, Pisani P and Parkin DM. Cancer, 106, 396–403.ĭennis Jr G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA. Virol., 65, 606–612.ĭalstein V, Riethmuller D, Pretet JL, Le Bail Carval K, Sautiere JL, Carbillet JP, Kantelip B, Schaal JP and Mougin C. Virol., 65, 4534–4538.Ĭullen AP, Reid R, Campion M and Lorincz AT. Cancer, 88, 63–73.Ĭouturier J, Sastre-Garau X, Schneider-Maunoury S, Labib A and Orth G. Cancer Res., 63, 1927–1935.Ĭlifford GM, Smith JS, Plummer M, Munoz N and Franceschi S. Cancer Inst., 88, 1361–1368.Ĭhen Y, Miller C, Mosher R, Zhao X, Deeds J, Morrissey M, Bryant B, Yang D, Meyer R, Cronin F, Gostout BS, Smith-McCune K and Schlegel R. Cancer Inst., 87, 796–802.īurger RA, Monk BJ, Kurosaki T, Anton-Culver H, Vasilev SA, Berman ML and Wilczynski SP. Cancer, 56, 640–645.īosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R and Shah KV. Soc., 57, 289–300.īerumen J, Casas L, Segura E, Amezcua JL and Garcia-Carranca A. HPV expression level may thus provide a biological marker useful for prognosis assessment and specific therapy of the disease.īenjamini Y and Hochberg Y. These findings suggest that HPV E6/E7 expression level plays a key role in the progression of invasive carcinoma of the uterine cervix via the deregulation of cellular genes controlling tumour cell proliferation. Moreover, we found that E6/E7 mRNA expression level was positively correlated with the expression level of the cluster genes and with viral DNA load. The average expression level of the genes of this cluster was higher in tumours with an early relapse than in tumours with a favourable course ( P=0.026). ![]() Most of these transcripts corresponded to E2F pathway genes controlling cell division or proliferation, whereas none was known as TP53 primary target. Using Coupled Two-Way Clustering and Sorting Points Into Neighbourhoods methods, we identified a ‘cervical cancer proliferation cluster’ composed of 163 highly correlated transcripts. To investigate molecular mechanisms involved in the progression of invasive cervical carcinoma, we performed a gene expression study on cases selected according to viral and clinical parameters. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. ![]()
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